Substance use is a serious concern in Arizona, driven by two drugs at once: fentanyl and methamphetamine. Both are major contributors to the state’s overdose deaths. Key figures:

• 1,655 methamphetamine-related overdose deaths in 2024.
• 60.5% of Arizona’s overdose deaths involved methamphetamine in 2024.
• Fentanyl was involved in 59% of fatal overdoses in Maricopa County in 2024, and meth in 67%, according to Maricopa County.
• Fentanyl and methamphetamine together are the most common drug combination in opioid deaths, at about half of cases, according to the Arizona Department of Health Services.
• Deaths involving fentanyl and meth rose roughly 40-fold since 1999.
• Overdose deaths have been leveling off after years of steep increases.

Arizona’s crisis has been shaped by the combination of fentanyl and methamphetamine, which are frequently found together in fatal overdoses. After years of steep increases, overdose deaths have recently begun to level off.

Arizona expanded Medicaid on January 1, 2014, covering adults up to 133% of the federal poverty level. The state’s Medicaid program, AHCCCS (Arizona Health Care Cost Containment System), covers addiction treatment. Of the 353 facilities listed below, 291 accept Medicaid.